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FBXO25

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Early spermatids, Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (JURKAT, SK-MEL-30)

Interaction

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).

Molecular function

Actin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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