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FBXO32

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class

Disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Breast myoepithelial cells, Prostatic glandular cells)

Immune cell specificity

Group enriched (naive CD8 T-cell, naive CD4 T-cell, T-reg, memory CD8 T-cell, memory CD4 T-cell, NK-cell, basophil, MAIT T-cell, gdT-cell)

Cell line specificity

Cell line enhanced (GAMG, HDLM-2, hTERT-RPE1, U-251 MG)

Interaction

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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