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FCN1

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
Protein class

Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (monocytes, Macrophages, Kupffer cells)

Immune cell specificity

Immune cell enhanced (classical monocyte, intermediate monocyte)

Cell line specificity

Group enriched (NB-4, U-937)

Interaction

Homotrimer (PubMed:17897951). Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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