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FCRL3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
Protein class
CD markers, Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (B-cells, NK-cells, dendritic cells, T-cells, Late spermatids, Early spermatids)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Cell line enriched (Daudi)
Interaction
Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70.
Molecular function
Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, IP, IF, ELISA
- Mouse Anti-FCRL3 Recombinant Antibody (clone CBF828) (MOB-068YJL)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC
- Mouse Anti-FCRL3 Recombinant Antibody (clone CB56YJ) (MOB-013YJL)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: FC, ELISA
- Human Anti-FCRL3 Recombinant Antibody (clone E9); scFv Fragment (HPAB-1151-FY-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-FCRL3 Recombinant Antibody (clone E3); scFv Fragment (HPAB-1150-FY-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, FC
- Human Anti-FCRL3 Recombinant Antibody (clone E9); Fab Fragment (HPAB-1151-FY-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-FCRL3 Recombinant Antibody (clone E3); Fab Fragment (HPAB-1150-FY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, FC
- Human Anti-FCRL3 Recombinant Antibody (clone E9) (HPAB-1151-FY)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
- Human Anti-FCRL3 Recombinant Antibody (clone E3) (HPAB-1150-FY)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.