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FECH
Catalyzes the ferrous insertion into protoporphyrin IX
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Erythroid cells, Distal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1, K-562, U-266/70)
Interaction
Homodimer (PubMed:17261801, PubMed:30765471). Interacts with PGRMC1; the interaction results in decreased FECH activity (PubMed:27599036). Interacts with ABCB10 and SLC25A37; this interaction forms an oligomeric complex (By similarity). Forms a complex with ABCB7 and ABCB10, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). Interacts with ABCB7 and ABCB10 (PubMed:30765471).
Molecular function
Lyase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, IF, IP
- Mouse Anti-FECH Recombinant Antibody (clone CBF3) (MOB-114YJL)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC-P, ELISA
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For Research Use Only. Not For Clinical Use.