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FGF6

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.
Protein class

Cancer-related genes, RAS pathway related proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Not detected

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (NTERA-2, REH)

Interaction

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Molecular function

Developmental protein, Growth factor, Mitogen

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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