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FGFBP1
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
Protein class
Cancer-related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Basal keratinocytes, Suprabasal keratinocytes, Basal respiratory cells, Squamous epithelial cells, Urothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HaCaT, HBEC3-KT)
Interaction
Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.
Molecular function
Growth factor binding
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.