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FHL3

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (granulocytes, Skeletal myocytes, NK-cells)

Immune cell specificity

Immune cell enriched (eosinophil)

Cell line specificity

Cell line enhanced (HEL)

Interaction

Interacts with SOX15; the interaction recruits FHL3 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.

Molecular function

Activator

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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