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FLG
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Suprabasal keratinocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, NTERA-2, TIME, U-2 OS, U-2197, WM-115)
Molecular function
Developmental protein
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, IHC-P
- Mouse Anti-FLG Recombinant Antibody (clone 38B1) (MOB-1398z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, IP, IF, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IHC-P
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.