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FLT3LG

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.
Protein class

RAS pathway related proteins

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (T-cells, NK-cells)

Immune cell specificity

Group enriched (T-reg, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell, naive CD8 T-cell, memory CD8 T-cell, gdT-cell)

Cell line specificity

Cell line enhanced (HDLM-2, U-266/70)

Interaction

Homodimer (isoform 2).

Molecular function

Cytokine

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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