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FLT4
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Hepatic stellate cells, Extravillous trophoblasts, Adipocytes, Endothelial cells)
Immune cell specificity
Immune cell enriched (MAIT T-cell)
Cell line specificity
Cell line enhanced (AN3-CA, BEWO, HEK93, HL-60, HUVEC TERT2, JURKAT, T-47d, TIME)
Interaction
Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP-2. Identified in a complex with SRC and ITGB1.
Molecular function
Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
- Recombinant Mouse Anti-Human FLT4 Antibody (MOB-2181MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, FC, IHC, IP
- Mouse Anti-Flt4 Recombinant Antibody (clone CBL842) (NEUT-851CQ)
-
- Species Reactivity: Mouse
- Type: Mouse IgG1
- Application: Neut
- Rat Anti-Flt4 Recombinant Antibody (clone AFL4) (NEUT-850CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a, κ
- Application: IHC, Block, ELISA, IP, WB
- Mouse Anti-FLT4 Recombinant Antibody (clone 4H4) (VS3-XY715)
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- Type: Mouse IgG1
- Application: ELISA, WB
- Anti-Human FLT4 Recombinant Antibody scFv Fragment (9D9F9) (TAB-015CQ-S(P))
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- Species Reactivity: Human
- Application: ELISA, FC
-
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Mouse Anti-FLT4 Recombinant Antibody (VS3-CJ913) (VS3-CJ913)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC
- Anti-Human FLT4 Recombinant Antibody (9D9F9) (TAB-015CQ)
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- Species Reactivity: Human
- Application: ELISA, FC
- Human Anti-FLT4 Recombinant Antibody (TAB-292CL) (TAB-292CL)
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- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IHC, FC
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
- Anti-Human FLT4 Recombinant Antibody Fab Fragment (9D9F9) (TAB-015CQ-F(E))
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- Species Reactivity: Human
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.