Intracellular, Membrane (different isoforms)
Cell type enhanced (dendritic cells, NK-cells, Langerhans cells, T-cells, monocytes, Macrophages, Plasma cells, B-cells, Kupffer cells)
Low immune cell specificity
Cell line enhanced (Karpas-707, MOLT-4, U-266/70)
Interacts with RAC1, PFN1 and PFN2 (By similarity). Interacts (activated by RAC1) with SRGAP2 (via SH3 domain); regulates the actin filament severing activity of FMNL1.
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For Research Use Only. Not For Clinical Use.