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FOS
Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including conditioned taste aversion; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to steroid hormone. Located in membrane; neuron projection; and nucleus. Biomarker of congestive heart failure; glomerulonephritis; and hypertension. Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit).
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (hTCEpi, OE19)
Interaction
Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site (PubMed:9732876). Interacts with SMAD3; the interaction is weak even on TGF-beta activation (PubMed:9732876). Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with CDS1 and PI4K2A (By similarity). Interacts (via bZIP domain and leucine-zipper region) with the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF) subunits SMARCB1, SMARCC2 and SMARCD1 (By similarity). Interacts (via bZIP domain and leucine-zipper region) with ARID1A (By similarity).
Molecular function
DNA-binding
More Types Infomation
Related Diseases
Colorectal Cancer
Endometrial Cancer
Gastric Cancer
Non-small Cell Lung Cancer
Insulin Resistance
Related Signaling Pathways
NLR Signaling Pathway
TNF Signaling Pathway
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
- Rabbit Anti-FOS Recombinant Antibody (clone JJ0938) (MRO-0355-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, FC
- Rabbit Anti-FOS Recombinant Antibody (clone AFY0074) (MOR-0103-FY)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
- Mouse Anti-FOS Recombinant Antibody (clone 5C3) (MOB-1611z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
- Mouse Anti-FOS Recombinant Antibody (VS3-WK1434) (VS3-WK1434)
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: FC
- Mouse Anti-FOS Recombinant Antibody (VS4-WK181) (VS4-WK181)
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: ELISA, WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF, FC
- Guinea pig Anti-FOS Recombinant Antibody (VS-0223-WK11) (VS-0223-WK11)
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- Derivation: Guinea pig
- Species Reactivity: Mouse, Rat, Human
- Type: Guinea pig IgG
- Application: WB, ICC, IHC, IHC-P
- Mouse Anti-FOS Recombinant Antibody (VS3-CJ229) (VS3-CJ229)
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- Species Reactivity: Human, Mouse, Rat
- Application: WB, IHC
- Mouse Anti-FOS Recombinant Antibody (clone 7D6) (VS3-CJ228)
-
- Species Reactivity: Human, Rat, Monkey
- Type: Mouse IgG1
- Application: WB
- Mouse Anti-FOS Recombinant Antibody (VS3-CJ227) (VS3-CJ227)
-
- Species Reactivity: Human, Mouse, Rat
- Application: WB, ELISA, IHC
-
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG
- Application: WB, IHC-P, IF
- Rabbit Anti-FOS Recombinant Antibody (VS-0223-WK10) (VS-0223-WK10)
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- Derivation: Rabbit
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IHC-P
- Mouse Anti-FOS Recombinant Antibody (clone 2G2) (VS3-XY720)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
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- Derivation: Mouse
- Species Reactivity: Human, Rat, Monkey
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human, Rat, Mouse
- Type: Mouse IgG1
- Application: WB, IHC
-
- Species Reactivity: Human, Rat, Monkey
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: IHC-P
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: ELISA, WB, IP
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