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FOSB
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Skeletal myocytes, Breast glandular cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Cell line enhanced (GAMG, HMC-1, hTCEpi, Karpas-707, SK-BR-3)
Interaction
Heterodimer; binds to DNA as heterodimer (PubMed:28981703). Component of an AP-1 transcription factor complex; composed of FOS-JUN heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with JUN, JUNB or JUND, thereby binding to the AP-1 consensus sequence and stimulating transcription (PubMed:28981703). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity). Interacts with ARID1A and JUN (By similarity). [Isoform 11]: Homodimer under oxidizing conditions and monomer under reducing conditions (in vitro) (PubMed:32542236). Heterodimer; binds to DNA as heterodimer (By similarity). Forms heterodimers with JUNB, JUN or JUND; thereby binding to the AP-1 consensus sequence but does not stimulate transcription (By similarity). Forms heterodimers with JUND under oxidizing conditions (PubMed:32542236).
Molecular function
DNA-binding
More Types Infomation
Related Diseases
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- Rabbit Anti-FOSB Recombinant Antibody (clone CBACN-228) (MRO-0598-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
- Rabbit Anti-FOSB Recombinant Antibody (VS3-CJ1035) (VS3-CJ1035)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
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For Research Use Only. Not For Clinical Use.