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FOSL1
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Metabolic proteins, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Urothelial cells, Basal prostatic cells, Suprabasal keratinocytes, Basal keratinocytes, Basal squamous epithelial cells, Squamous epithelial cells, Prostatic glandular cells)
Immune cell specificity
Immune cell enriched (myeloid DC)
Cell line specificity
Cell line enhanced (PC-3, U-2197, WM-115)
Interaction
Heterodimer (By similarity). Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity). Interacts with ARID1A and JUN (By similarity).
Molecular function
DNA-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.