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FOXA1
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Urothelial cells, Basal prostatic cells, Prostatic glandular cells, Breast glandular cells, Enteroendocrine cells, Basal squamous epithelial cells, Respiratory ciliated cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2, MCF7, PC-3, RT4, SK-BR-3, T-47d)
Interaction
Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).
Molecular function
Activator, Chromatin regulator, Developmental protein, DNA-binding, Repressor
More Types Infomation
- Recombinant Mouse Anti-Human FOXA1 Antibody (MOB-1057MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
- Rabbit Anti-FOXA1 Recombinant Antibody (clone JF10-02) (MRO-0599-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, ELISA
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IP
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For Research Use Only. Not For Clinical Use.