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FOXO4
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, RAS pathway related proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Syncytiotrophoblasts, Cytotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enriched (BEWO)
Interaction
Interacts with CREBBP/CBP, CTNNB1, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CREBBP/CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding. Interacts with USP7; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of TP53. Interacts with NLK, and this inhibits monoubiquitination and transcriptional activity. Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity).
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation
Related Diseases
Gastric Cancer
Hepatocellular Carcinoma
Related Signaling Pathways
Insulin Signaling Pathway
PI3K-Akt Signaling Pathway
- Rabbit Anti-FOXO4 Recombinant Antibody (clone CBACN-231) (MRO-0604-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP, FC
- Rabbit Anti-FOXO4 Recombinant Antibody (clone CBACN-230) (MRO-0603-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Derivation: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP, FC
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For Research Use Only. Not For Clinical Use.