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FSHR

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
Protein class

Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Granulosa cells, Excitatory neurons, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (PubMed:24692546). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (PubMed:17030088).

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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