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FZD1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
Protein class
Cancer-related genes, G-protein coupled receptors, Plasma proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Horizontal cells, Cholangiocytes, Peritubular cells, Basal prostatic cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (AF22, HSkMC)
Interaction
Interacts with MYOC (PubMed:19188438). Interacts with WNT7B (By similarity). (Microbial infection) Interacts with C.difficile toxin TcdB; frizzled receptors constitute the major host receptors for TcdB in the colonic epithelium.
Molecular function
Developmental protein, G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.