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FZD8
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Protein class
G-protein coupled receptors, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Muller glia cells, Alveolar cells type 1, Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-RPE1, PC-3, U-138 MG, U-251 MG)
Interaction
Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly with LRP5 or LRP6; the interaction is promoted by Wnt-binding and signaling and inhibited by DKK1. Interacts with GPOC, RSPO1 and RSPO3 (By similarity). Interacts with glypican GPC3 (PubMed:24496449).
Molecular function
Developmental protein, G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P
- Rabbit Anti-FZD8 Recombinant Antibody (clone JB40-16) (MRO-0609-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.