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GABBR2
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166, HUVEC TERT2, U-138 MG)
Interaction
Heterodimer of GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:10906333, PubMed:10773016, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Homodimers may form, but are inactive (PubMed:15617512). Interacts (via C-terminus) with ATF4 (via leucine zipper domain) (By similarity).
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IP, WB
- Rabbit Anti-GABBR2 Recombinant Antibody (clone JU31-32) (MRO-0617-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC, IF
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
- Human Anti-GABBR2 Recombinant Antibody (clone hN81/37.1) (VS-0422-LC87)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB
- Rat Anti-GABBR2 Recombinant Antibody (clone rtN81/37.1) (VS-0422-LC86)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB
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For Research Use Only. Not For Clinical Use.