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GABRB1

Engineered Antibody
GABRB1 (Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1) is a Protein Coding gene. This gene encodes GABA A receptor, beta 1 subunit. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. Diseases associated with GABRB1 include Developmental And Epileptic Encephalopathy 45 and Schizoaffective Disorder.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Group enriched (Astrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (REH, U-87 MG)

Interaction

Binds UBQLN1 (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity).

Molecular function

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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