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GABRG2
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons, Bipolar cells)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (CACO-2, Karpas-707, RPMI-8226, SuSa, U-266/70, U-266/84)
Interaction
Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (PubMed:2538761, PubMed:29950725). Interacts with GABARAP (PubMed:9892355). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).
Molecular function
Chloride channel, Ion channel
More Types Infomation
- Mouse Anti-GABRG2 Recombinant Antibody (clone 10F10-C1-B8) (FAMAB-1353CQ)
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- Species Reactivity: Rat
- Type: Mouse IgG2b
- Application: IP, WB, IF, IHC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ICC, IHC, IP
- Rabbit Anti-Gabrg2 Recombinant Antibody (VS-0522-LC103) (VS-0522-LC103)
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- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: IP, WB, IF, IHC
- Rat Anti-Gabrg2 Recombinant Antibody (VS-0522-LC102) (VS-0522-LC102)
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- Species Reactivity: Rat
- Type: Rat IgG2b
- Application: IP, WB, IF, IHC
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For Research Use Only. Not For Clinical Use.