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GADD45G
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Syncytiotrophoblasts)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Group enriched (HDLM-2, SCLC-21H)
Interaction
Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA.
Molecular function
Developmental protein
More Types Infomation
Related Diseases
Breast Cancer
Endometrial Cancer
Throid Cancer
Related Signaling Pathways
p53 Signaling Pathway
- Recombinant Mouse Anti-Human GADD45G Antibody (MOB-2432MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
- Chicken Anti-GADD45G Polyclonal IgY (BRD-0215MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.