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GAP43

Engineered Antibody
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein class

Plasma proteins, Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, NTERA-2, SCLC-21H, SH-SY5Y, U-87 MG)

Interaction

Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity).

Molecular function

Calmodulin-binding, Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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