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GATA1
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Erythroid cells)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Group enriched (HEL, HMC-1, K-562)
Interaction
May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with BRD3 (By similarity). Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo (By similarity). Interacts with EP300. Interacts with MED1, CCAR1 and CALCOCO1. Interacts with CEBPE (PubMed:26019275).
Molecular function
Activator, DNA-binding, Repressor
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
- Rabbit Anti-GATA1 Recombinant Antibody (clone JA10-32) (MRO-0636-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, IP, ChIP
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC/IF, IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, ICC, FC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, IF, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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For Research Use Only. Not For Clinical Use.