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GATA3

Engineered Antibody
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts, Cytotrophoblasts, Breast glandular cells, Suprabasal keratinocytes)

Immune cell specificity

Group enriched (T-reg, memory CD4 T-cell, NK-cell, memory CD8 T-cell, MAIT T-cell, naive CD4 T-cell, gdT-cell, naive CD8 T-cell)

Cell line specificity

Cell line enhanced (BEWO, MCF7, RT4, SH-SY5Y, T-47d)

Interaction

Interacts with TBX21 ('Tyr-530' phosphorylated form).

Molecular function

Activator, DNA-binding

More Types Infomation
Related Diseases
Inflammatory Bowel Diseases Inflammatory Bowel Diseases

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