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GBP2

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Glandular and luminal cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC diff, EFO-21, HDLM-2, HUVEC TERT2, RT4)

Interaction

Homodimer; homodimerization occurs upon GTP-binding and is required for the association with membranous structures. Heterodimer with other family members, including GBP1, GBP3, GBP4 and GBP5.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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