GBP5

Intracellular

Cell type enhanced (NK-cells, T-cells, dendritic cells, Plasma cells)

Immune cell enhanced (T-reg)

Cell line enhanced (EFO-21, NB-4, U-266/70, U-937)

Homodimer (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric (PubMed:20180847). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).

Antimicrobial, Hydrolase