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GCNT1
Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Kupffer cells, Proximal enterocytes)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (HHSteC, HSkMC, U-2197)
Interaction
Interacts with GOLPH3; may control GCNT1 retention in the Golgi.
Molecular function
Glycosyltransferase, Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, Dot, FuncS
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For Research Use Only. Not For Clinical Use.