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Gdf5
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, granulocytes, Basal prostatic cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, BJ hTERT+, GAMG, HHSteC, HSkMC, U-87 MG)
Interaction
Homodimer; disulfide-linked (By similarity). Interacts with serine proteases, HTRA1 and HTRA3 (By similarity). Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8. Interacts with high affinity with NOG; inhibits chondrogenesis. Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD dependent signaling. Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).
Molecular function
Cytokine, Growth factor
More Types Infomation
- Rat Anti-Gdf5 Recombinant Antibody (clone CBL552) (NEUT-868CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b
- Application: Neut
- Rat Anti-Gdf5 Recombinant Antibody (clone CBL873) (NEUT-867CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: Neut, WB
- Rat Anti-Gdf5 Recombinant Antibody (clone CBL272) (NEUT-866CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2b
- Application: ELISA, Neut
- Rat Anti-Gdf5 Recombinant Antibody (clone 13J15) (NEUT-865CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2
- Application: Neut, WB
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- Derivation: Phage display library
- Species Reactivity: Human, Predicted to work with: Does not react with Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.