Transporters
Intracellular
Cell type enhanced (Late spermatids, Spermatocytes)
Low immune cell specificity
Low cell line specificity
Monomer (Probable). Interacts with GGA2 and GGA3 (PubMed:14638859). Binds to clathrin and activated ARFs, including ARF1, ARF5 and ARF6 (PubMed:11301005, PubMed:11950392, PubMed:12679809, PubMed:15143060, PubMed:22522702). Interacts with RABEP1 (PubMed:12505986, PubMed:15143060, PubMed:14665628). Interacts with RABGEF1 (PubMed:12505986, PubMed:15143060). Interacts with the type-I membrane proteins LRP3, M6PR/CD-MPR and IGF2R/CI-MPR (PubMed:11390366, PubMed:11387475, PubMed:12060753). Interacts (via N-terminal VHS domain) with SORL1/sorLA and SORT1 (via C-terminal cytosolic domain) (PubMed:11821067, PubMed:17855360, PubMed:20015111). Interacts with EPN4 (PubMed:12538641). Interacts with CCDC91 (PubMed:12808037, PubMed:12858163). Interacts with HEATR5B/p200a (PubMed:12808037, PubMed:15758025). Interacts with SYNRG/gamma-synergin (PubMed:10814529, PubMed:12808037, PubMed:15758025). Interacts (via GAE doamin) with NECAP1 and NECAP2 (PubMed:14665628). Interacts (via GAE domain) with AFTPH/aftiphilin (PubMed:14665628, PubMed:15758025). Interacts with TSG101 and UBC (PubMed:14660606, PubMed:15143060). Interacts with RNF11 (PubMed:20676133). Interacts (via VHS domain) with BACE1 (via DXXLL motif); the interaction highly increases when BACE1 is phosphorylated at 'Ser-498' (PubMed:14567678, PubMed:15886016). Interacts with CNST (By similarity). Interacts with ADRA2B (PubMed:27901063). Interacts with ARL3; the interaction recruits, in collaboration with RABEP1, PKD1:PKD2 complex to trans-Golgi network and is required for ciliary targeting (By similarity).
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For Research Use Only. Not For Clinical Use.