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GJA1
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Granulosa cells, Suprabasal keratinocytes, Astrocytes, Alveolar cells type 1, Basal keratinocytes, Endometrial stromal cells, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-RPE1, HUVEC TERT2, NTERA-2, SuSa, U-87 MG)
Interaction
A connexon is composed of a hexamer of connexins. Interacts (via C-terminus) with TJP1 (By similarity). Interacts (via C-terminus) with SRC (via SH3 domain) (By similarity). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with SGSM3 and CNST (By similarity). Interacts with RIC1/CIP150. Interacts with CSNK1D. Interacts with NOV (PubMed:15181016, PubMed:15213231). Interacts with TMEM65 (By similarity).
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC
- Rabbit Anti-GJA1 Recombinant Antibody (clone AFY0059) (MOR-0088-FY)
-
- Species Reactivity: Human, Mouse, Rat, Bovine (P)
- Type: Rabbit IgG
- Application: ICC, IHC-P, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, ICC, IF, IHC-P
- Rabbit Anti-GJA1 Polyclonal Antibody (MRO-1784-CN) (MRO-1784-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC
- Mouse Anti-GJA1 Recombinant Antibody; Fab Fragment (HPAB-M0497-YC-F(E)) (HPAB-M0497-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: IHC, Inhib, FuncS
- Mouse Anti-GJA1 Recombinant Antibody; Fab Fragment (HPAB-M0496-YC-F(E)) (HPAB-M0496-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: IHC, Inhib, FuncS
- Mouse Anti-GJA1 Recombinant Antibody; scFv Fragment (HPAB-M0497-YC-S(P)) (HPAB-M0497-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: IHC, Inhib, FuncS
- Mouse Anti-GJA1 Recombinant Antibody; scFv Fragment (HPAB-M0496-YC-S(P)) (HPAB-M0496-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: IHC, Inhib, FuncS
- Mouse Anti-GJA1 Recombinant Antibody (HPAB-M0497-YC) (HPAB-M0497-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, Inhib, FuncS
- Mouse Anti-GJA1 Recombinant Antibody (HPAB-M0496-YC) (HPAB-M0496-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: IHC, Inhib, FuncS
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For Research Use Only. Not For Clinical Use.