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GKN2
The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa.
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Gastric mucus-secreting cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, HaCaT, HMC-1, MOLT-4, NTERA-2, PC-3, U-2 OS, U-266/70)
Interaction
Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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For Research Use Only. Not For Clinical Use.