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GLS2
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatocytes, Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431, Daudi, Hep G2, SCLC-21H)
Interaction
Homotetramer, dimer of dimers (Probable). Does not assemble into higher oligomers (By similarity). Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with the PDZ domain of TAX1BP3 (PubMed:11163757).
Molecular function
Hydrolase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, WB
- Mouse Anti-GLS2 Recombinant Antibody (VS3-WK1197) (VS3-WK1197)
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- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.