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GNRH1

GNRH1 encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in GNRH1 are associated with hypogonadotropic hypogonadism.
Protein class

Disease related genes, Human disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Leydig cells, Peritubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SCLC-21H)

Molecular function

Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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