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gp120 & CD3

In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope. The 120 in its name comes from its molecular weight of 120 kDa. Gp120 is essential for virus entry into cells as it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. Binding to CD4 induces the start of a cascade of conformational changes in gp120 and gp41 that lead to the fusion of the viral membrane with the host cell membrane. Binding to CD4 is mainly electrostatic although there are van der Waals interactions and hydrogen bonds.Envelope glycoprotein GP120 (or gp120) is a glycoprotein exposed on the surface of the HIV envelope.
    • Target: gp120
    • Linker: mc(maleimidocaproyl)
    • Drug: MMAF (monomethyl auristatin F)
  • TRX4 (Gly-002CL)
    • Target: gp120
    • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
    • Drug: MMAE (monomethyl auristatin E)
    • Target: gp120
    • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)

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