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GPLD1

Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane.
Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Inhibitory neurons, Cone photoreceptor cells, Hepatocytes, Excitatory neurons, Oligodendrocyte precursor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (Daudi, U-698)

Interaction

Monomer.

Molecular function

Hydrolase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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