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GRAP2
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (granulocytes, Macrophages, NK-cells, T-cells, Erythroid cells)
Immune cell specificity
Group enriched (naive CD8 T-cell, memory CD8 T-cell, gdT-cell, MAIT T-cell, memory CD4 T-cell, T-reg, naive CD4 T-cell)
Cell line specificity
Group enriched (HEL, JURKAT, K-562, MOLT-4)
Interaction
Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB. Interacts with PTPN23.
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, FC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.