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GREM2
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity).
Protein class
Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Syncytiotrophoblasts)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (fHDF/TERT166)
Interaction
Homodimer. Interacts with BMP2, BMP4 and BMP7, but has lower affinity for BMP7 than for BMP2 and BMP4. Binds heparin; this impairs the interaction with BMP2.
Molecular function
Cytokine, Developmental protein, Heparin-binding
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA
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For Research Use Only. Not For Clinical Use.