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Gene
GSK3A

GSK3A

Engineered Antibody

This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]

Protein class

Cancer-related genes, Enzymes

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin (PubMed:17229088). Interacts with CTNND2 (PubMed:19706605). Interacts with LMBR1L (PubMed:31073040). Interacts with DDX3X (PubMed:18846110). Interacts with TNFRSF10B (PubMed:18846110). Interacts with RICTOR; the interaction results in phosphorylation of RICTOR at 'Thr-1695' by GSK3A which facilitates FBXW7-mediated ubiquitination and subsequent degradation of RICTOR (PubMed:25897075). (Microbial infection) Interacts with M.tuberculosis PtpA.

Molecular function

Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase

More Types Infomation

Related Signaling Pathways

BCR Signaling Pathway

Canonical Wnt Signaling Pathway

ErbB Signaling Pathway

Non-Canonical Wnt Signaling Pathway

PI3K-Akt Signaling Pathway

Related Diseases

Breast Cancer

Endometrial Cancer

Prostate Cancer

Throid Cancer

Hepatocellular Carcinoma

Insulin Resistance

Rabbit Anti-GSK3A Polyclonal Antibody (MRO-1914-CN) (MRO-1914-CN)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC

Recombinant Mouse Anti-Human GSK3A Antibody (clone 7H3G2,7H3G3) (MOB-2450MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-Fr, IHC-P, WB

Rabbit Anti-GSK3A Recombinant Antibody (clone DS1525AB) (MOR-1525)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IP

Mouse Anti-GSK3A Recombinant Antibody (clone 5B8-H1-B3) (VS3-QX480)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA

Mouse Anti-GSK3A Recombinant Antibody (clone 1B10-G3-E9) (VS3-QX479)
- Derivation: Mouse
- Species Reactivity: Human
- Application: WB, IHC, ICC, FC, ELISA

Rabbit Anti-GSK3A Recombinant Antibody (clone 4A5) (ZG-0696J)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC

Chicken Anti-GSK3a Polyclonal IgY (BRD-0237MZ)
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: Indirect ELISA, WB

Mouse Anti-GSK3A Recombinant Antibody (clone 6G12C2) (VS3-XY782)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB

Rabbit Anti-GSK3A/GSK3B (phospho Y216/Y279) Recombinant Antibody (VS3-CJ998) (VS3-CJ998)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IP

Mouse Anti-GSK3A Recombinant Antibody (ZG-0400J) (ZG-0400J)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA

Mouse Anti-GSK3A Recombinant Antibody (ZG-0399J) (ZG-0399J)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, ELISA

Mouse Anti-GSK3A Recombinant Antibody (ZG-0398J) (ZG-0398J)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA

Recombinant Rabbit Anti-GSK3A Antibody (clone R08-8G7) (VS3-FY623)
- Species Reactivity: Human, Rat, Hamster
- Type: Rabbit IgG
- Application: WB

Recombinant Rabbit Anti-GSK3A Antibody (clone R07-3A2) (VS3-FY622)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP

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