GSTZ1

GSTZ1 gene is a member of theglutathione S-transferase (GSTs) super-family which encodesmultifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens,mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1is a bifunctional protein which has minimalglutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomeraseactivity. GSTZ1 catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. GSTZ1 participates in thecatabolism of phenylalanine and tyrosine. Thus defects in GSTZ1 cause harshmetabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia.