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GUCY2D

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Group enriched (Cone photoreceptor cells, Rod photoreceptor cells)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enriched (JURKAT)

Interaction

Homodimer; requires homodimerization for guanylyl cyclase activity (By similarity). Interacts with RD3; promotes the exit of GUCY2D from the endoplasmic reticulum and its trafficking to the photoreceptor outer segments (PubMed:21928830, PubMed:21078983). Interaction with RD3 negatively regulates guanylate cyclase activity (PubMed:21928830).

Molecular function

Lyase

More Types Infomation

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