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HAVCR2
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Protein class
CD markers, Disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hofbauer cells, Kupffer cells, dendritic cells, Macrophages, granulocytes, NK-cells, Langerhans cells, Proximal tubular cells, monocytes)
Immune cell specificity
Group enriched (myeloid DC, NK-cell, intermediate monocyte, classical monocyte, non-classical monocyte)
Cell line specificity
Cell line enhanced (ASC diff, Daudi, HDLM-2, HMC-1, RPMI-8226)
Interaction
Interacts with HMGB1; impairs HMGB1 binding to B-DNA and likely HMGB1-mediated innate immune response (By similarity). Interacts with BAG6 (By similarity). Interacts (phosphorylated) with PIK3R1 and PIK3R2. Interacts (not dependent on its phosphorylation status) with FYN (By similarity). Interacts (in basal state T-cells) with VAV1; AKT1/2, LCP2, ZAP70, SYK, PIK3R1, FYN, SH3BP2 and SH2D2A. Interacts (in activated T-cells) with LCK and PLCG (PubMed:26492563, PubMed:24337741). Interacts with ILF3; this interaction promotes ILF3 ubiquitination and degradation (PubMed:34110282).
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Rat Anti-Havcr2 Recombinant Antibody (clone RMT3-23) (NEUT-894CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG2a
- Application: Block, FC
- Rat Anti-Havcr2 Recombinant Antibody (clone B8.2C12) (NEUT-893CQ)
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- Species Reactivity: Mouse
- Type: Rat IgG1
- Application: Block, FC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, FC, ICC
- Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0512-CN-S(P)) (HPAB-0512-CN-S(P))
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized scFv
- Application: ELISA, FC, IHC
- Mouse Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0511-CN-S(P)) (HPAB-0511-CN-S(P))
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC, IHC
- Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0510-CN-S(P)) (HPAB-0510-CN-S(P))
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized scFv
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0509-CN-S(P)) (HPAB-0509-CN-S(P))
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0508-CN-S(P)) (HPAB-0508-CN-S(P))
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0507-CN-S(P)) (HPAB-0507-CN-S(P))
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-0506-CN-S(P)) (HPAB-0506-CN-S(P))
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse scFv
- Application: ELISA, FC
- Human Anti-HAVCR2 Recombinant Antibody (HPAB-0513-CN) (HPAB-0513-CN)
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized IgG1
- Application: ELISA, FC, IHC
- Human Anti-HAVCR2 Recombinant Antibody (HPAB-0512-CN) (HPAB-0512-CN)
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized IgG4
- Application: ELISA, FC, IHC
- Mouse Anti-HAVCR2 Recombinant Antibody (HPAB-0511-CN) (HPAB-0511-CN)
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse IgG
- Application: ELISA, FC, IHC
- Human Anti-HAVCR2 Recombinant Antibody (HPAB-0510-CN) (HPAB-0510-CN)
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- Derivation: Humanized
- Species Reactivity: Human, Cynomolgus
- Type: Humanized IgG1, κ
- Application: ELISA, FC
- Human Anti-HAVCR2 Recombinant Antibody (HPAB-0509-CN) (HPAB-0509-CN)
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- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human, Cynomolgus
- Type: Chimeric (mouse/human) IgG1, κ
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody (HPAB-0508-CN) (HPAB-0508-CN)
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse IgG
- Application: ELISA, FC
- Mouse Anti-HAVCR2 Recombinant Antibody (HPAB-0507-CN) (HPAB-0507-CN)
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- Species Reactivity: Human, Cynomolgus
- Type: Mouse IgG
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.