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HBEGF

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Basal prostatic cells, Urothelial cells, Squamous epithelial cells)

Immune cell specificity

Group enriched (intermediate monocyte, non-classical monocyte, myeloid DC)

Cell line specificity

Cell line enhanced (HBF TERT88, JURKAT, TIME, U-698)

Interaction

Interacts with FBLN1 (By similarity). Interacts with EGFR and ERBB4.

Molecular function

Growth factor, Heparin-binding, Receptor

More Types Infomation

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