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HCN1
HCN1 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 1) is a Protein Coding gene. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. Diseases associated with HCN1 include Developmental And Epileptic Encephalopathy 24 and Generalized Epilepsy With Febrile Seizures Plus, Type 10.
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (WM-115)
Interaction
Homotetramer (PubMed:28086084). Heterotetramer with HCN2. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCNE2. Interacts with the SH3 domain of CSK (By similarity).
Molecular function
Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel
More Types Infomation
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- Species Reactivity: Human
- Application: WB
- Rabbit Anti-HCN1 Recombinant Antibody (clone rN70/28) (VS-0422-LC116)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: ICC, WB, IF, IHC
- Human Anti-HCN1 Recombinant Antibody (clone hN70/28) (VS-0422-LC115)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: ICC, WB, IF, IHC
- Rat Anti-HCN1 Recombinant Antibody (clone rtN70/28) (VS-0422-LC114)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: ICC, WB, IF, IHC
- Mouse Anti-HCN1 Recombinant Antibody (clone mN70/28) (VS-0422-LC113)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: ICC, WB, IF, IHC
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For Research Use Only. Not For Clinical Use.