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HDGF

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Protein class

Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Monomer, and domain-swapped homodimer (PubMed:17270212). [Isoform 1]: Interacts with nuclear proteins NCL and YBX1/YB1 (PubMed:26845719). [Isoform 2]: Interacts with cytoskeletal proteins such as actin, dynein, tubulin and vimentin (PubMed:26845719). [Isoform 3]: Interacts with cytoskeletal proteins such as dynein and tubulin but does not interact with actin or vimentin (PubMed:26845719).

Molecular function

DNA-binding, Growth factor, Heparin-binding, Repressor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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