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HHIP
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (Oligodendrocytes, Alveolar cells type 2, Theca cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HUVEC TERT2, TIME)
Interaction
Interacts with all three hedgehog family members, SHH, IHH and DHH.
More Types Infomation
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.