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HLA-DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
Protein class

Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (B-cells, Langerhans cells, monocytes, Macrophages, Alveolar cells type 2, Kupffer cells, dendritic cells)

Immune cell specificity

Immune cell enhanced (naive B-cell, myeloid DC)

Cell line specificity

Cell line enhanced (Daudi, HDLM-2, REH, U-698)

Interaction

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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