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HLA-DPA1
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
Protein class
Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Langerhans cells, monocytes, Macrophages, Kupffer cells, B-cells)
Immune cell specificity
Group enriched (myeloid DC, intermediate monocyte, memory B-cell, naive B-cell, non-classical monocyte, plasmacytoid DC, classical monocyte)
Cell line specificity
Cell line enhanced (Daudi, HDLM-2, REH, U-698)
Interaction
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
More Types Infomation
- APC-B*44:02/Human HLA-DPA1 (EEAGAAFSF) MHC Tetramer (MHC-LC1524)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGAAFSF
- Conjugate: APC
- APC-B*44:02/Human HLA-DPA1 (EEFGRAASF) MHC Tetramer (MHC-LC1521)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGRAASF
- Conjugate: APC
- APC-B*44:02/Human HLA-DPA1 (EEFGAAFSF) MHC Tetramer (MHC-LC1518)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGAAFSF
- Conjugate: APC
- APC-B*44:02/Human HLA-DPA1 (EEAGRAFSF) MHC Tetramer (MHC-LC1515)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGRAFSF
- Conjugate: APC
- APC-B*44:05/Human HLA-DPA1 (EEFGRAYGF) MHC Tetramer (MHC-LC1251)
-
- Class: Class I
- Antigen: HLA-DPA1
- Antigen Species: Human
- Peptide: EEFGRAYGF
- Conjugate: APC
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGAAFSF
- Conjugate: BV421
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGRAFSF
- Conjugate: BV421
-
- Class: Class I
- Antigen: HLA-DPA1
- Antigen Species: Human
- Peptide: EEFGRAYGF
- Conjugate: BV421
-
- Class: Class I
- Antigen: HLA-DPA*0201
- Antigen Species: Human
- Peptide: EEFGRAFSF
- Conjugate: BV421
- APC-B*44:02/Human HLA-DPA1 (EEFGRAFSF) MHC Tetramer (MHC-LC1203)
-
- Class: Class I
- Antigen: HLA-DPA*0201
- Antigen Species: Human
- Peptide: EEFGRAFSF
- Conjugate: APC
- PE-B*44:02/Human HLA-DPA1 (EEFGAAFSF) MHC Tetramer (MHC-LC1517)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGAAFSF
- Conjugate: PE
- PE-B*44:02/Human HLA-DPA1 (EEAGRAFSF) MHC Tetramer (MHC-LC1514)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGRAFSF
- Conjugate: PE
- PE-B*44:02/Human HLA-DPA1 (EEFGRAASF) MHC Tetramer (MHC-LC1520)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGRAASF
- Conjugate: PE
- APC-B*44:02/Human HLA-DPA1 (EEFGAAASF) MHC Tetramer (MHC-LC1527)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGAAASF
- Conjugate: APC
- PE-B*44:05/Human HLA-DPA1 (EEFGRAYGF) MHC Tetramer (MHC-LC1250)
-
- Class: Class I
- Antigen: HLA-DPA1
- Antigen Species: Human
- Peptide: EEFGRAYGF
- Conjugate: PE
- PE-B*44:02/Human HLA-DPA1 (EEFGRAFSF) MHC Tetramer (MHC-LC1202)
-
- Class: Class I
- Antigen: HLA-DPA*0201
- Antigen Species: Human
- Peptide: EEFGRAFSF
- Conjugate: PE
- PE-B*44:02/Human HLA-DPA1 (EEAGAAFSF) MHC Tetramer (MHC-LC1523)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGAAFSF
- Conjugate: PE
- PE-B*44:02/Human HLA-DPA1 (EEFGAAASF) MHC Tetramer (MHC-LC1526)
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGAAASF
- Conjugate: PE
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEFGRAASF
- Conjugate: BV421
-
- Class: Class I
- Antigen: HLA-DPA*02:01
- Antigen Species: Human
- Peptide: EEAGAAFSF
- Conjugate: BV421
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For Research Use Only. Not For Clinical Use.